Phase 1 testing of detoxified LPS/group B meningococcal outer membrane protein vaccine with and without synthetic CPG 7909 adjuvant for the prevention and treatment of sepsis

BACKGROUND: Gram-negative bacteria (GNB) are a leading cause of nosocomial infection and sepsis. Increasing multi-antibiotic resistance has left clinicians with fewer therapeutic options. Antibodies to GNB lipopolysaccharide (LPS, or endotoxin) have reduced morbidity and mortality as a result of inf...

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Detalhes bibliográficos
Publicado no:Vaccine
Main Authors: Cross, Alan S., Greenberg, Nancy, Billington, Melissa, Zhang, Lei, DeFilippi, Christopher, May, Ryan C., Bajwa, Kanwaldeep K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679452/
https://ncbi.nlm.nih.gov/pubmed/26514420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2015.10.072
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