Enhanced antibody production in mice to the malaria antigen AMA1 by CPG 7909 requires physical association of CpG and antigen

CpG oligodeoxynucleotides are potent immunostimulants. In this study, CPG 7909 was formulated with the recombinant Plasmodium falciparum protein AMA1-C1 adsorbed to Alhydrogel (aluminum hydroxide) and used to immunize mice. Mice receiving free CPG 7909 in a separate same site injection to the AMA1-C...

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Detalhes bibliográficos
Main Authors: Mullen, Gregory E. D., Aebig, Joan A., Dobrescu, Gelu, Rausch, Kelly, Lambert, Lynn, Long, Carole A., Miles, Aaron P., Saul, Allan
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1997297/
https://ncbi.nlm.nih.gov/pubmed/17566616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2007.05.007
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