Phase 1 Trial of AMA1-C1/Alhydrogel plus CPG 7909: An Asexual Blood-Stage Vaccine for Plasmodium falciparum Malaria

BACKGROUND: Apical Membrane Antigen 1 (AMA1), a polymorphic merozoite surface protein, is a leading blood-stage malaria vaccine candidate. This is the first reported use in humans of an investigational vaccine, AMA1-C1/Alhydrogel, with the novel adjuvant CPG 7909. METHODS: A phase 1 trial was conduc...

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Detalhes bibliográficos
Main Authors: Mullen, Gregory E. D., Ellis, Ruth D., Miura, Kazutoyo, Malkin, Elissa, Nolan, Caroline, Hay, Mhorag, Fay, Michael P., Saul, Allan, Zhu, Daming, Rausch, Kelly, Moretz, Samuel, Zhou, Hong, Long, Carole A., Miller, Louis H., Treanor, John
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2491586/
https://ncbi.nlm.nih.gov/pubmed/18698359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002940
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