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Phase 1 Trial of AMA1-C1/Alhydrogel plus CPG 7909: An Asexual Blood-Stage Vaccine for Plasmodium falciparum Malaria

BACKGROUND: Apical Membrane Antigen 1 (AMA1), a polymorphic merozoite surface protein, is a leading blood-stage malaria vaccine candidate. This is the first reported use in humans of an investigational vaccine, AMA1-C1/Alhydrogel, with the novel adjuvant CPG 7909. METHODS: A phase 1 trial was conduc...

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書誌詳細
主要な著者: Mullen, Gregory E. D., Ellis, Ruth D., Miura, Kazutoyo, Malkin, Elissa, Nolan, Caroline, Hay, Mhorag, Fay, Michael P., Saul, Allan, Zhu, Daming, Rausch, Kelly, Moretz, Samuel, Zhou, Hong, Long, Carole A., Miller, Louis H., Treanor, John
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2008
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2491586/
https://ncbi.nlm.nih.gov/pubmed/18698359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002940
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