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Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi

Genetic engineering technologies can be used both to create transgenic mosquitoes carrying antipathogen effector genes targeting human malaria parasites and to generate gene-drive systems capable of introgressing the genes throughout wild vector populations. We developed a highly effective autonomou...

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Bibliographische Detailangaben
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Gantz, Valentino M., Jasinskiene, Nijole, Tatarenkova, Olga, Fazekas, Aniko, Macias, Vanessa M., Bier, Ethan, James, Anthony A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679060/
https://ncbi.nlm.nih.gov/pubmed/26598698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521077112
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