Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis

Systemic sclerosis (SSc) is a multisystem autoimmune disorder with clinical manifestations resulting from tissue fibrosis and extensive vasculopathy. A potential disease susceptibility gene for SSc is IFN regulatory factor 5 (IRF5), whose SNP is associated with milder clinical manifestations; howeve...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Saigusa, Ryosuke, Asano, Yoshihide, Taniguchi, Takashi, Yamashita, Takashi, Ichimura, Yohei, Takahashi, Takehiro, Toyama, Tetsuo, Yoshizaki, Ayumi, Sugawara, Koji, Tsuruta, Daisuke, Taniguchi, Tadatsugu, Sato, Shinichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679033/
https://ncbi.nlm.nih.gov/pubmed/26598674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520997112
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