Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer

Aberrant transcription of the pericentromeric human satellite II (HSATII) repeat is present in a wide variety of epithelial cancers. In deriving experimental systems to study its deregulation, we observed that HSATII expression is induced in colon cancer cells cultured as xenografts or under nonadhe...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Bersani, Francesca, Lee, Eunjung, Kharchenko, Peter V., Xu, Andrew W., Liu, Mingzhu, Xega, Kristina, MacKenzie, Olivia C., Brannigan, Brian W., Wittner, Ben S., Jung, Hyunchul, Ramaswamy, Sridhar, Park, Peter J., Maheswaran, Shyamala, Ting, David T., Haber, Daniel A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679016/
https://ncbi.nlm.nih.gov/pubmed/26575630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518008112
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