Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer

Aberrant transcription of the pericentromeric human satellite II (HSATII) repeat is present in a wide variety of epithelial cancers. In deriving experimental systems to study its deregulation, we observed that HSATII expression is induced in colon cancer cells cultured as xenografts or under nonadhe...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bersani, Francesca, Lee, Eunjung, Kharchenko, Peter V., Xu, Andrew W., Liu, Mingzhu, Xega, Kristina, MacKenzie, Olivia C., Brannigan, Brian W., Wittner, Ben S., Jung, Hyunchul, Ramaswamy, Sridhar, Park, Peter J., Maheswaran, Shyamala, Ting, David T., Haber, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679016/
https://ncbi.nlm.nih.gov/pubmed/26575630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518008112
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