Knockout of the Tumor suppressor gene Gprc5a in mice leads to NF-κB activation in airway epithelium and promotes lung inflammation and tumorigenesis

Mouse models can be useful for increasing the understanding of lung tumorigenesis and assessing the potential of chemopreventive agents. We explored the role of inflammation in lung tumor development in mice with knockout of the tumor suppressor Gprc5a. Examination of normal lung tissue and tumors f...

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Veröffentlicht in:Cancer Prev Res (Phila)
Hauptverfasser: Deng, Jiong, Fujimoto, Junya, Ye, Xiao-Feng, Men, Tao-Yan, Van Pelt, Carolyn S., Chen, Yu-Long, Lin, Xiao-Feng, Kadara, Humam, Tao, Qingguo, Lotan, Dafna, Lotan, Reuben
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678967/
https://ncbi.nlm.nih.gov/pubmed/20354164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-10-0032
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