Wild-type p53 reactivation by small-molecule Minnelide™ in human papillomavirus (HPV)-positive head and neck squamous cell carcinoma

OBJECTIVES: The incidence of high-risk human papillomavirus (HR-HPV) head and neck squamous cell carcinoma (HNSCC) continues to increase, particularly oropharyngeal squamous cell carcinoma (OPSCC) cases. The inactivation of the p53 tumor suppressor gene promotes a chain of molecular events, includin...

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Veröffentlicht in:Oral Oncol
Hauptverfasser: Caicedo-Granados, Emiro, Lin, Rui, Clements-Green, Caitlin, Yueh, Bevan, Sangwan, Veena, Saluja, Ashok
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678773/
https://ncbi.nlm.nih.gov/pubmed/25311433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.oraloncology.2014.09.013
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