Identifying gene-gene interactions that are highly associated with Body Mass Index using Quantitative Multifactor Dimensionality Reduction (QMDR)

BACKGROUND: Despite heritability estimates of 40–70 % for obesity, less than 2 % of its variation is explained by Body Mass Index (BMI) associated loci that have been identified so far. Epistasis, or gene-gene interactions are a plausible source to explain portions of the missing heritability of BMI...

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Veröffentlicht in:BioData Min
Hauptverfasser: De, Rishika, Verma, Shefali S., Drenos, Fotios, Holzinger, Emily R., Holmes, Michael V., Hall, Molly A., Crosslin, David R., Carrell, David S., Hakonarson, Hakon, Jarvik, Gail, Larson, Eric, Pacheco, Jennifer A., Rasmussen-Torvik, Laura J., Moore, Carrie B., Asselbergs, Folkert W., Moore, Jason H., Ritchie, Marylyn D., Keating, Brendan J., Gilbert-Diamond, Diane
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678717/
https://ncbi.nlm.nih.gov/pubmed/26674805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13040-015-0074-0
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