Inhalation of the Reactive Aldehyde Acrolein Promotes Antigen Sensitization to Ovalbumin and Enhances Neutrophilic Inflammation

Acrolein (ACR), an α,β-unsaturated aldehyde and a major component of tobacco smoke, is a highly reactive electrophilic respiratory irritant implicated in asthma pathogenesis and severity. However, few studies have directly investigated the influence of ACR exposure on allergen sensitization and pulm...

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Publicado en:J Immunotoxicol
Autores principales: O’Brien, Edmund, Spiess, Page C., Habibovic, Aida, Hristova, Milena, Bauer, Robert A., Randall, Matthew J., Poynter, Matthew E., van der Vliet, Albert
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678038/
https://ncbi.nlm.nih.gov/pubmed/25875327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/1547691X.2015.1033571
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