Towards Fibroid Gene Therapy: Adenovirus-Mediated Delivery of Herpes Simplex Virus 1 Thymidine Kinase Gene/Ganciclovir Shrinks Uterine Leiomyoma in the Eker Rat Model

BACKGROUND/AIMS: The objective of this study was to assess in vivo gene therapy of uterine leiomyomas in the Eker rat model using adenovirus (Ad)-mediated delivery of herpes simplex virus 1 thymidine kinase gene (HSV1TK) followed by ganciclovir (GCV) treatment. METHODS: We randomized 27 female Eker...

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Detalhes bibliográficos
Publicado no:Gynecol Obstet Invest
Main Authors: Hassan, Memy, Zhang, Dong, Salama, Salama, Hamada, Farid, Arafa, Hossam, Fouad, Hala, Walker, Cheryl, Al-Hendy, Ayman
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2009
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677717/
https://ncbi.nlm.nih.gov/pubmed/19325244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000209675
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