Myeloperoxidase–Hepatocyte–Stellate Cell Cross Talk Promotes Hepatocyte Injury and Fibrosis in Experimental Nonalcoholic Steatohepatitis

Aims: Myeloperoxidase (MPO), a highly oxidative enzyme secreted by leukocytes has been implicated in human and experimental nonalcoholic steatohepatitis (NASH), but the underlying mechanisms remain unknown. In this study, we investigated how MPO contributes to progression from steatosis to NASH. Res...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Antioxid Redox Signal
Main Authors: Pulli, Benjamin, Ali, Muhammad, Iwamoto, Yoshiko, Zeller, Matthias W.G., Schob, Stefan, Linnoila, Jenny J., Chen, John W.
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2015
Teme:
Original Research Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677570/
https://ncbi.nlm.nih.gov/pubmed/26058518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2014.6108
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