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Myeloperoxidase–Hepatocyte–Stellate Cell Cross Talk Promotes Hepatocyte Injury and Fibrosis in Experimental Nonalcoholic Steatohepatitis

Aims: Myeloperoxidase (MPO), a highly oxidative enzyme secreted by leukocytes has been implicated in human and experimental nonalcoholic steatohepatitis (NASH), but the underlying mechanisms remain unknown. In this study, we investigated how MPO contributes to progression from steatosis to NASH. Res...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Pulli, Benjamin, Ali, Muhammad, Iwamoto, Yoshiko, Zeller, Matthias W.G., Schob, Stefan, Linnoila, Jenny J., Chen, John W.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677570/
https://ncbi.nlm.nih.gov/pubmed/26058518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2014.6108
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