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Critical role of the α1-Na(+),K(+)-ATPase subunit in insensitivity of rodent cells to cytotoxic action of ouabain
In rodents, ubiquitous α1-Na(+),K(+)-ATPase is inhibited by ouabain and other cardiotonic steroids (CTS) at ~10(3)-fold higher concentrations than those effective in other mammals. To examine the specific roles of the CTS-sensitive α1S- and CTS-resistant α1R-Na(+),K(+)-ATPase isoforms, we compared t...
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| Publicado no: | Apoptosis |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4677477/ https://ncbi.nlm.nih.gov/pubmed/26067145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-015-1144-y |
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