CRISPR/CAS9-Mediated Genome Editing of miRNA-155 Inhibits Proinflammatory Cytokine Production by RAW264.7 Cells

MicroRNA 155 (miR-155) is a key proinflammatory regulator in clinical and experimental rheumatoid arthritis (RA). Here we generated a miR-155 genome knockout (GKO) RAW264.7 macrophage cell line using the clustered regulatory interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Jing, Weixia, Zhang, Xuewu, Sun, Wenyan, Hou, Xiujuan, Yao, Zhongqiang, Zhu, Yuelan
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677169/
https://ncbi.nlm.nih.gov/pubmed/26697483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/326042
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