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Increased neurovirulence and reactivation of the herpes simplex virus type 1 latency associated transcript (LAT) negative mutant dLAT2903 with a disrupted LAT miR-H2

At least six microRNAs (miRNAs) appear to be encoded by the latency associated transcript (LAT) of herpes simplex virus type 1 (HSV-1). The gene for ICP0, an important immediate early (IE) viral protein, is antisense to, and overlaps with, the region of LAT from which miRNA H2 (miR-H2) is derived. W...

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Detalhes bibliográficos
Publicado no:J Neurovirol
Main Authors: Jiang, Xianzhi, Brown, Don, Osorio, Nelson, Hsiang, Chinhui, BenMohamed, Lbachir, Wechsler, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676951/
https://ncbi.nlm.nih.gov/pubmed/26069184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13365-015-0362-y
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