The Herpes Simplex Virus Type 1 Latency-Associated Transcript Can Protect Neuron-Derived C1300 and Neuro2A Cells from Granzyme B-Induced Apoptosis and CD8 T-Cell Killing

The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) is the only HSV-1 gene transcript abundantly expressed throughout latency. LAT null mutants have a significantly reduced reactivation phenotype. LAT's antiapoptosis activity is the major LAT factor involved in supportin...

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Detalhes bibliográficos
Main Authors: Jiang, Xianzhi, Alami Chentoufi, Aziz, Hsiang, Chinhui, Carpenter, Dale, Osorio, Nelson, BenMohamed, Lbachir, Fraser, Nigel W., Jones, Clinton, Wechsler, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067767/
https://ncbi.nlm.nih.gov/pubmed/21177822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01791-10
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