Charge Shielding of PIP(2) by Cations Regulates Enzyme Activity of Phospholipase C

Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP(2)) of the plasma membrane by phospholipase C (PLC) generates two critical second messengers, inositol-1,4,5-trisphosphate and diacylglycerol. For the enzymatic reaction, PIP(2) binds to positively charged amino acids in the pleckstrin homolog...

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Udgivet i:PLoS One
Main Authors: Seo, Jong Bae, Jung, Seung-Ryoung, Huang, Weigang, Zhang, Qisheng, Koh, Duk-Su
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676720/
https://ncbi.nlm.nih.gov/pubmed/26658739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144432
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