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Charge Shielding of PIP(2) by Cations Regulates Enzyme Activity of Phospholipase C
Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP(2)) of the plasma membrane by phospholipase C (PLC) generates two critical second messengers, inositol-1,4,5-trisphosphate and diacylglycerol. For the enzymatic reaction, PIP(2) binds to positively charged amino acids in the pleckstrin homolog...
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| I publikationen: | PLoS One |
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| Huvudupphovsmän: | , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Public Library of Science
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4676720/ https://ncbi.nlm.nih.gov/pubmed/26658739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144432 |
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