Synthesis of ent-Ketorfanol via a C–H Alkenylation/Highly Torquoselective 6π-Electrocyclization Cascade

The asymmetric synthesis of ent-ketorfanol from simple and commercially available precursors is reported. A Rh(I)-catalyzed intramolecular C–H alkenylation/highly torquoselective 6π-electrocyclization cascade provides a fused bicyclic 1,2-dihydropyridine as a key intermediate. Computational studies...

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Udgivet i:Angew Chem Int Ed Engl
Main Authors: Phillips, Eric M., Mesganaw, Tehetena, Patel, Ashay, Duttwyler, Simon, Mercado, Brandon Q., Houk, Kendall N., Ellman, Jonathan A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676713/
https://ncbi.nlm.nih.gov/pubmed/26385263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201505604
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