The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development

The lysine-specific histone methyltransferase KMT2D has emerged as one of the most frequently mutated genes in follicular lymphoma (FL) and diffuse large B cell lymphoma (DLBCL). However, the biological consequences of KMT2D mutations on lymphoma development are not known. Here we show that KMT2D fu...

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Published in:Nat Med
Main Authors: Ortega-Molina, Ana, Boss, Isaac W., Canela, Andres, Pan, Heng, Jiang, Yanwen, Zhao, Chunying, Jiang, Man, Hu, Deqing, Agirre, Xabier, Niesvizky, Itamar, Lee, Ji-Eun, Chen, Hua-Tang, Ennishi, Daisuke, Scott, David W., Mottok, Anja, Hother, Christoffer, Liu, Shichong, Cao, Xing-Jun, Tam, Wayne, Shaknovich, Rita, Garcia, Benjamin A., Gascoyne, Randy D., Ge, Kai, Shilatifard, Ali, Elemento, Olivier, Nussenzweig, Andre, Melnick, Ari M., Wendel, Hans-Guido
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676270/
https://ncbi.nlm.nih.gov/pubmed/26366710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3943
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