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Therapy: Metformin takes a new route to clinical efficacy

Metformin is currently the first-line treatment option for patients with type 2 diabetes mellitus, yet its mechanism of action remains uncertain. A new study reveals the important role for the activation of a duodenal AMPK-dependent neuronal pathway in the acute antihyperglycaemic effect of metformi...

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Pubblicato in:Nat Rev Endocrinol
Autori principali: Foretz, Marc, Viollet, Benoit
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676264/
https://ncbi.nlm.nih.gov/pubmed/26032104
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