Identifying kinase dependency in cancer cells by integrating high-throughput drug screening and kinase inhibition data

Motivation: Targeted kinase inhibitors have dramatically improved cancer treatment, but kinase dependency for an individual patient or cancer cell can be challenging to predict. Kinase dependency does not always correspond with gene expression and mutation status. High-throughput drug screens are po...

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Enregistré dans:
Détails bibliographiques
Publié dans:Bioinformatics
Auteurs principaux: Ryall, Karen A., Shin, Jimin, Yoo, Minjae, Hinz, Trista K., Kim, Jihye, Kang, Jaewoo, Heasley, Lynn E., Tan, Aik Choon
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Original Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675831/
https://ncbi.nlm.nih.gov/pubmed/26206305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btv427
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