Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels

Voltage-gated sodium (Na(V)) channels contain an α-subunit incorporating the channel’s pore and gating machinery composed of four homologous domains (DI–DIV), with a pore domain formed by the S5 and S6 segments and a voltage-sensor domain formed by the S1–S4 segments. During a membrane depolarizatio...

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Bibliographic Details
Published in:Biophys J
Main Authors: Sheets, Michael F., Fozzard, Harry A., Hanck, Dorothy A.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2015
Subjects:
Channels and Transporters
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675820/
https://ncbi.nlm.nih.gov/pubmed/26636939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.10.012
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