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Molecular Model of Anticonvulsant Drug Binding to the Voltage-Gated Sodium Channel Inner Pore

The tricyclic anticonvulsant drugs phenytoin, carbamazepine, and lamotrigine block neuronal voltage-gated Na(+) channels, and their binding sites to domain IV-S6 in the channel's inner pore overlap with those of local anesthetic drugs. These anticonvulsants are neutral, in contrast to the mostl...

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Detalhes bibliográficos
Main Authors: Lipkind, Gregory M., Fozzard, Harry A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981395/
https://ncbi.nlm.nih.gov/pubmed/20643904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.064683
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