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Molecular Model of Anticonvulsant Drug Binding to the Voltage-Gated Sodium Channel Inner Pore
The tricyclic anticonvulsant drugs phenytoin, carbamazepine, and lamotrigine block neuronal voltage-gated Na(+) channels, and their binding sites to domain IV-S6 in the channel's inner pore overlap with those of local anesthetic drugs. These anticonvulsants are neutral, in contrast to the mostl...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The American Society for Pharmacology and Experimental Therapeutics
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2981395/ https://ncbi.nlm.nih.gov/pubmed/20643904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.064683 |
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