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Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras.

The NF1 gene, which is altered in patients with type 1 neurofibromatosis, encodes neurofibromin, a protein whose GTPase-activating function can negatively regulate GTP-Ras by accelerating its conversion to inactive GDP-Ras. In schwannoma cell lines from patients with neurofibromatosis, loss of neuro...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Johnson, M R, Look, A T, DeClue, J E, Valentine, M B, Lowy, D R
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46756/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8516298/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.12.5539
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