Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance

The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly overexpressed in cancers and is implicated in the development of chemoresistance. The use of drugs inhibiting MGMT has been hindered by their haematologic toxicity and inefficiency. As a different strategy to inhibit MGM...

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Опубликовано в: :Nat Commun
Главные авторы: Wickström, Malin, Dyberg, Cecilia, Milosevic, Jelena, Einvik, Christer, Calero, Raul, Sveinbjörnsson, Baldur, Sandén, Emma, Darabi, Anna, Siesjö, Peter, Kool, Marcel, Kogner, Per, Baryawno, Ninib, Johnsen, John Inge
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Pub. Group 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674781/
https://ncbi.nlm.nih.gov/pubmed/26603103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9904
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