Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance

The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly overexpressed in cancers and is implicated in the development of chemoresistance. The use of drugs inhibiting MGMT has been hindered by their haematologic toxicity and inefficiency. As a different strategy to inhibit MGM...

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Foilsithe in:Nat Commun
Main Authors: Wickström, Malin, Dyberg, Cecilia, Milosevic, Jelena, Einvik, Christer, Calero, Raul, Sveinbjörnsson, Baldur, Sandén, Emma, Darabi, Anna, Siesjö, Peter, Kool, Marcel, Kogner, Per, Baryawno, Ninib, Johnsen, John Inge
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Pub. Group 2015
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674781/
https://ncbi.nlm.nih.gov/pubmed/26603103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9904
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