Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance

The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly overexpressed in cancers and is implicated in the development of chemoresistance. The use of drugs inhibiting MGMT has been hindered by their haematologic toxicity and inefficiency. As a different strategy to inhibit MGM...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wickström, Malin, Dyberg, Cecilia, Milosevic, Jelena, Einvik, Christer, Calero, Raul, Sveinbjörnsson, Baldur, Sandén, Emma, Darabi, Anna, Siesjö, Peter, Kool, Marcel, Kogner, Per, Baryawno, Ninib, Johnsen, John Inge
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674781/
https://ncbi.nlm.nih.gov/pubmed/26603103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9904
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