The Oncogenic Roles of DICER1 RNase IIIb Domain Mutations in Ovarian Sertoli-Leydig Cell Tumors()()

DICER1, an endoribonuclease required for microRNA (miRNA) biogenesis, is essential for embryogenesis and the development of many organs including ovaries. We have recently identified somatic hotspot mutations in RNase IIIb domain of DICER1 in half of ovarian Sertoli-Leydig cell tumors, a rare class...

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Publicat a:Neoplasia
Autors principals: Wang, Yemin, Chen, Jiamin, Yang, Winnie, Mo, Fan, Senz, Janine, Yap, Damian, Anglesio, Michael S., Gilks, Blake, Morin, Gregg B., Huntsman, David G.
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674484/
https://ncbi.nlm.nih.gov/pubmed/26408257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2015.08.003
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