Antitumor Activity of KW-2450 Against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases

Currently, no targeted drug is available for triple-negative breast cancer (TNBC), an aggressive breast cancer that does not express estrogen receptor, progesterone receptor, or HER2. TNBC has high mitotic activity, and since Aurora A and B mitotic kinases drive cell division and are overexpressed i...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Kai, Kazuharu, Kondo, Kimie, Wang, Xiaoping, Xie, Xuemei, Pitner, Mary K., Reyes, Monica E., Torres-Adorno, Angie M., Masuda, Hiroko, Hortobagyi, Gabriel N., Bartholomeusz, Chandra, Saya, Hideyuki, Tripathy, Debu, Sen, Subrata, Ueno, Naoto T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674309/
https://ncbi.nlm.nih.gov/pubmed/26443806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0096
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