The sphingosine kinase 2 inhibitor ABC294640 reduces the growth of prostate cancer cells and results in accumulation of dihydroceramides in vitro and in vivo

Despite recent advances in the development of novel therapies against castration resistant prostate cancer, the advanced form of the disease remains a major treatment challenge. Aberrant sphingolipid signaling through sphingosine kinases and their product sphingosine-1-phosphate can promote prolifer...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Venant, Heather, Rahmaniyan, Mehrdad, Jones, E. Ellen, Lu, Ping, Lilly, Michael B., Garrett-Mayer, Elizabeth, Drake, Richard R., Kraveka, Jacqueline M., Smith, Charles D., Voelkel-Johnson, Christina
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674301/
https://ncbi.nlm.nih.gov/pubmed/26494858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0279
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