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Microcephaly protein Asp focuses the minus ends of spindle microtubules at the pole and within the spindle

Depletion of Drosophila melanogaster Asp, an orthologue of microcephaly protein ASPM, causes spindle pole unfocusing during mitosis. However, it remains unclear how Asp contributes to pole focusing, a process that also requires the kinesin-14 motor Ncd. We show that Asp localizes to the minus ends o...

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Vydáno v:J Cell Biol
Hlavní autoři: Ito, Ami, Goshima, Gohta
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674282/
https://ncbi.nlm.nih.gov/pubmed/26644514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201507001
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