A reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors

The human 2-oxoglutarate (2OG) dependent oxygenases belong to a family of structurally related enzymes that play important roles in many biological processes. We report that competition-based NMR methods, using 2OG as a reporter ligand, can be used for quantitative and site-specific screening of lig...

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Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Leung, Ivanhoe K. H., Demetriades, Marina, Hardy, Adam P., Lejeune, Clarisse, Smart, Tristan J., Szöllössi, Andrea, Kawamura, Akane, Schofield, Christopher J., Claridge, Timothy D. W.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673903/
https://ncbi.nlm.nih.gov/pubmed/23234607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301583m
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