SUMOylation of TARBP2 regulates miRNA/siRNA efficiency

Small RNA-induced gene silencing is essential for post-transcriptional regulation of gene expression; however, it remains unclear how miRNA/siRNA efficiency is regulated. Here we show that TARBP2 is SUMOylated at K52, which can be enhanced by its phosphorylation. This modification can stabilize TARB...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Chen, Cheng, Zhu, Changhong, Huang, Jian, Zhao, Xian, Deng, Rong, Zhang, Hailong, Dou, Jinzhuo, Chen, Qin, Xu, Ming, Yuan, Haihua, Wang, Yanli, Yu, Jianxiu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673853/
https://ncbi.nlm.nih.gov/pubmed/26582366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9899
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