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The tyrosine kinase inhibitor imatinib prevents lung injury and death after intravenous LPS in mice

Severe sepsis and septic shock are frequent causes of the acute respiratory distress syndrome, and important sources of human mortality. Lipopolysaccharide (LPS), a component of Gram-negative bacterial cell walls, plays a major role in the pathogenesis of severe sepsis and septic shock. LPS exposure...

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Publicat a:Physiol Rep
Autors principals: Stephens, R Scott, Johnston, Laura, Servinsky, Laura, Kim, Bo S, Damarla, Mahendra
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673626/
https://ncbi.nlm.nih.gov/pubmed/26620257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12589
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