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Protein kinase G increases antioxidant function in lung microvascular endothelial cells by inhibiting the c-Abl tyrosine kinase

Oxidant injury contributes to acute lung injury (ALI). We previously reported that activation of protein kinase G(I) (PKG(I)) posttranscriptionally increased the key antioxidant enzymes catalase and glutathione peroxidase 1 (Gpx-1) and attenuated oxidant-induced cytotoxicity in mouse lung microvascu...

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Detalhes bibliográficos
Main Authors: Stephens, R. Scott, Servinsky, Laura E., Rentsendorj, Otgonchimeg, Kolb, Todd M., Pfeifer, Alexander, Pearse, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948974/
https://ncbi.nlm.nih.gov/pubmed/24401847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00375.2012
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