Impact of Long-Term Exposure to the Tyrosine Kinase Inhibitor Imatinib on the Skeleton of Growing Rats

The tyrosine kinase (TK) inhibitor imatinib provides a highly effective therapy for chronic myeloid leukemia (CML) via inhibition of the oncogenic TK BCR-ABL1. However, off-target TKs like platelet-derived growth factor receptors (PDGF-R) and colony-stimulating factor-1 receptor (c-fms), involved in...

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Foilsithe in:PLoS One
Main Authors: Tauer, Josephine T., Hofbauer, Lorenz C., Jung, Roland, Gerdes, Sebastian, Glauche, Ingmar, Erben, Reinhold G., Suttorp, Meinolf
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479438/
https://ncbi.nlm.nih.gov/pubmed/26107505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131192
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