Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma

Advances in the molecular biology of medulloblastoma revealed four genetically and clinically distinct subgroups. Group 3 medulloblastomas are characterized by frequent amplifications of the oncogene MYC, a high incidence of metastasis, and poor prognosis despite aggressive therapy. We investigated...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Faria, Claudia C., Agnihotri, Sameer, Mack, Stephen C., Golbourn, Brian J., Diaz, Roberto J., Olsen, Samantha, Bryant, Melissa, Bebenek, Matthew, Wang, Xin, Bertrand, Kelsey C., Kushida, Michelle, Head, Renee, Clark, Ian, Dirks, Peter, Smith, Christian A., Taylor, Michael D., Rutka, James T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2015
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673298/
https://ncbi.nlm.nih.gov/pubmed/26061748
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