Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A

mTORC1 is a master regulator of cell growth and proliferation, and an established anticancer drug target. Aberrant mTORC1 signaling is common in hepatocellular carcinoma (HCC), but the underlying mechanism remains elusive. Rab1A is a newly identified mTORC1 activator that mediates an alternative ami...

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Pubblicato in:Oncotarget
Autori principali: Xu, Bi-Hong, Li, Xiao-Xing, Yang, Yang, Zhang, Mei-Yin, Rao, Hui-Lan, Wang, Hui-Yun, Zheng, X.F. Steven
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Priority Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673231/
https://ncbi.nlm.nih.gov/pubmed/26308575
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