MYC amplifications in myeloma cell lines: correlation with MYC-inhibitor efficacy

In multiple myeloma, elevated MYC expression is related to disease initiation and progression. We found that in myeloma cell lines, MYC gene amplifications were common and correlated with MYC mRNA and protein. In primary cell samples MYC mRNA levels were also relatively high; however gene copy numbe...

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發表在:Oncotarget
Main Authors: Holien, Toril, Misund, Kristine, Olsen, Oddrun Elise, Baranowska, Katarzyna Anna, Buene, Glenn, Børset, Magne, Waage, Anders, Sundan, Anders
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2015
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673192/
https://ncbi.nlm.nih.gov/pubmed/26087190
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