Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells

Cells degrade proteins either by proteasomes that clinically are targeted by for example bortezomib or carfilzomib, or by formation of autophagosomes and lysosomal degradation that can be inhibited by hydroxychloroquine (HCQ). Multiple myeloma is unique among cancers because proteasomal inhibition h...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Baranowska, Katarzyna, Misund, Kristine, Starheim, Kristian K., Holien, Toril, Johansson, Ida, Darvekar, Sagar, Buene, Glenn, Waage, Anders, Bjørkøy, Geir, Sundan, Anders
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342593/
https://ncbi.nlm.nih.gov/pubmed/27683126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12226
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