Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species(†)

BACKGROUND: Piperlongumine (PL) is a compound isolated from the piper longum plant. It possesses anti-cancer activities through blocking the transcription factor STAT3 and by inducing reactive oxygen species (ROS) in cancer, but not normal cells. It also inhibits platelet aggregation induced by coll...

Full description

Saved in:
Bibliographic Details
Published in:PLoS One
Main Authors: Yuan, Hengjie, Houck, Katie L., Tian, Ye, Bharadwaj, Uddalak, Hull, Ken, Zhou, Zhou, Zhou, Mingzhao, Wu, Xiaoping, Tweardy, David J., Romo, Daniel, Fu, Xiaoyun, Zhang, Yanjun, Zhang, Jianning, Dong, Jing-fei
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672935/
https://ncbi.nlm.nih.gov/pubmed/26645674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143964
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items