Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species(†)

BACKGROUND: Piperlongumine (PL) is a compound isolated from the piper longum plant. It possesses anti-cancer activities through blocking the transcription factor STAT3 and by inducing reactive oxygen species (ROS) in cancer, but not normal cells. It also inhibits platelet aggregation induced by coll...

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Pubblicato in:PLoS One
Autori principali: Yuan, Hengjie, Houck, Katie L., Tian, Ye, Bharadwaj, Uddalak, Hull, Ken, Zhou, Zhou, Zhou, Mingzhao, Wu, Xiaoping, Tweardy, David J., Romo, Daniel, Fu, Xiaoyun, Zhang, Yanjun, Zhang, Jianning, Dong, Jing-fei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672935/
https://ncbi.nlm.nih.gov/pubmed/26645674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143964
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