Enhancing potency of siRNA targeting fusion genes by optimization outside of target sequence

Canonical siRNA design algorithms have become remarkably effective at predicting favorable binding regions within a target mRNA, but in some cases (e.g., a fusion junction site) region choice is restricted. In these instances, alternative approaches are necessary to obtain a highly potent silencing...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Gavrilov, Kseniya, Seo, Young-Eun, Tietjen, Gregory T., Cui, Jiajia, Cheng, Christopher J., Saltzman, W. Mark
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2015
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672813/
https://ncbi.nlm.nih.gov/pubmed/26627251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1517039112
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