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Enhancing potency of siRNA targeting fusion genes by optimization outside of target sequence
Canonical siRNA design algorithms have become remarkably effective at predicting favorable binding regions within a target mRNA, but in some cases (e.g., a fusion junction site) region choice is restricted. In these instances, alternative approaches are necessary to obtain a highly potent silencing...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4672813/ https://ncbi.nlm.nih.gov/pubmed/26627251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1517039112 |
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