The bone-sparing effects of estrogen and WNT16 are independent of each other

Wingless-type MMTV integration site family (WNT)16 is a key regulator of bone mass with high expression in cortical bone, and Wnt16(−/−) mice have reduced cortical bone mass. As Wnt16 expression is enhanced by estradiol treatment, we hypothesized that the bone-sparing effect of estrogen in females i...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Movérare-Skrtic, Sofia, Wu, Jianyao, Henning, Petra, Gustafsson, Karin L., Sjögren, Klara, Windahl, Sara H., Koskela, Antti, Tuukkanen, Juha, Börjesson, Anna E., Lagerquist, Marie K., Lerner, Ulf H., Zhang, Fu-Ping, Gustafsson, Jan-Åke, Poutanen, Matti, Ohlsson, Claes
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672787/
https://ncbi.nlm.nih.gov/pubmed/26627248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520408112
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