Compromising the phosphodependent regulation of the GABA(A)R β3 subunit reproduces the core phenotypes of autism spectrum disorders

Alterations in the efficacy of neuronal inhibition mediated by GABA(A) receptors (GABA(A)Rs) containing β3 subunits are continually implicated in autism spectrum disorders (ASDs). In vitro, the plasma membrane stability of GABA(A)Rs is potentiated via phosphorylation of serine residues 408 and 409 (...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Vien, Thuy N., Modgil, Amit, Abramian, Armen M., Jurd, Rachel, Walker, Joshua, Brandon, Nicholas J., Terunuma, Miho, Rudolph, Uwe, Maguire, Jamie, Davies, Paul A., Moss, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672772/
https://ncbi.nlm.nih.gov/pubmed/26627235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514657112
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