Compromising the phosphodependent regulation of the GABA(A)R β3 subunit reproduces the core phenotypes of autism spectrum disorders

Alterations in the efficacy of neuronal inhibition mediated by GABA(A) receptors (GABA(A)Rs) containing β3 subunits are continually implicated in autism spectrum disorders (ASDs). In vitro, the plasma membrane stability of GABA(A)Rs is potentiated via phosphorylation of serine residues 408 and 409 (...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Vien, Thuy N., Modgil, Amit, Abramian, Armen M., Jurd, Rachel, Walker, Joshua, Brandon, Nicholas J., Terunuma, Miho, Rudolph, Uwe, Maguire, Jamie, Davies, Paul A., Moss, Stephen J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2015
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672772/
https://ncbi.nlm.nih.gov/pubmed/26627235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514657112
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