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Compromising the phosphodependent regulation of the GABA(A)R β3 subunit reproduces the core phenotypes of autism spectrum disorders
Alterations in the efficacy of neuronal inhibition mediated by GABA(A) receptors (GABA(A)Rs) containing β3 subunits are continually implicated in autism spectrum disorders (ASDs). In vitro, the plasma membrane stability of GABA(A)Rs is potentiated via phosphorylation of serine residues 408 and 409 (...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4672772/ https://ncbi.nlm.nih.gov/pubmed/26627235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514657112 |
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