Compromising the phosphodependent regulation of the GABA(A)R β3 subunit reproduces the core phenotypes of autism spectrum disorders

Alterations in the efficacy of neuronal inhibition mediated by GABA(A) receptors (GABA(A)Rs) containing β3 subunits are continually implicated in autism spectrum disorders (ASDs). In vitro, the plasma membrane stability of GABA(A)Rs is potentiated via phosphorylation of serine residues 408 and 409 (...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Vien, Thuy N., Modgil, Amit, Abramian, Armen M., Jurd, Rachel, Walker, Joshua, Brandon, Nicholas J., Terunuma, Miho, Rudolph, Uwe, Maguire, Jamie, Davies, Paul A., Moss, Stephen J.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672772/
https://ncbi.nlm.nih.gov/pubmed/26627235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514657112
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