The Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-Fungal Immunity and Intestinal Inflammation

CARD9 is a central component of anti-fungal innate immune signaling via C-type lectin receptors, and several immune-related disorders are associated with CARD9 mutations. Here we used a rare CARD9 variant that confers protection against inflammatory bowel disease as an entry point to investigate CAR...

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Vydáno v:Immunity
Hlavní autoři: Cao, Zhifang, Conway, Kara L., Heath, Robert J., Rush, Jason S., Leshchiner, Elizaveta S., Ramirez-Ortez, Zaida G., Nedelsky, Natalia B., Huang, Hailiang, Ng, Aylwin, Gardet, Agnès, Cheng, Shih-Chin, Shamji, Alykhan F., Rioux, John D., Wijmenga, Cisca, Netea, Mihai G., Means, Terry K., Daly, Mark J., Xavier, Ramnik J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672733/
https://ncbi.nlm.nih.gov/pubmed/26488816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.10.005
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